The current study is innovative for investigating GxE effects using a polygenic approach within a developmentally-sensitive design. Including those that have already been mentioned, there are several additional implications for future research. Different phenotypic targets for PRS may be warranted for researchers who are primarily interested in GxE (e.g., stress sensitivity). Alternatively, researchers can focus on testing GxE using genes that have already been (or will be) identified through GWAS, although having “high quality” environment measures will be important for these types of studies (Caspi et al., 2010). From a clinical perspective, PRS has the potential to explain a significant amount of the variation in psychiatric disorders as sample sizes increase but the current findings fall well short of being able to make any clinically meaningful predictions. Investigating environmental influences simultaneously with genetic information may be crucial for enhancing our abilities to make accurate diagnostic predictions down the line.
