frequency of rescue analgesic administration was observed (F 2,120 = 5.336, P = 0.006). Post hoc analysis revealed significant differences between the A/A and A/G genotypes (P = 0.005) and between the A/A and G/G genotypes (P = 0.010), indicating that the carriers of the A/A genotype in the A1032G SNP required rescue analgesics more often compared with carriers of the A/G and G/G genotypes (Figure 2A). The effect of KCNJ6 A1032G on the total dose of rescue analgesics administered was not significant (F 2,120 = 1.332, P = 0.268). However, a significant main effect of the KCNJ6 A1032G SNP on the total dose of rescue analgesics administered was observed in the female subjects (F 2,49 = 3.428, P = 0.040), and differences were significant between the A/A and A/G genotypes (P = 0.040) and marginally significant between the A/A and G/G genotypes (P = 0.061) in the post hoc analysis (Figure 2B), whereas such differences were not observed in male subjects (F 2,68 = 0.032, P = 0.969). Neither the main effect of gender nor the SNP×gender interaction was significant (data not shown). Significant associations were not observed between the two SNPs and NRS pain scores (G-1250A: F 2,94
