uses a 36-point visual analog scale to rate the extent of response and thus allows for a broader range of effect and greater variability for comparisons. In addition, the small sample size, although larger relative to past studies that have tested the effects of rs1799971 on measures of alcohol sensitivity and alcohol consumption, also represents a limitation of the current study. As effect sizes for any single variant will be small, future research should employ larger samples to characterize the extent of rs3778150 and rs1799971’s influence on alcohol response and alcohol use. Furthermore, given that the sample was limited to moderate drinkers, it is unclear how these findings might generalize to lighter or heavier-drinking individuals. Future studies might also evaluate how these variants relate to subjective response in the presence of higher or lower doses of alcohol. However, a major strength of the current study was the inclusion of rs3778150 in order to provide the first test of this variant in relation to alcohol sensitivity and alcohol use phenotypes. A related strength was the utilization of numerous measures of alcohol response, and thus the ability to examine the relations of two putatively causal genetic variants in OPRM1 with self-report and
