The intrinsic differences between studies in iMOs and humans raise the question of the utility of using flies and worms for identifying individual genes and genetic pathways relevant for AUD. In this review, we address this issue by assessing the overlap—at the level of individual genes— between genetic results from studies on alcohol-related behaviors in iMOs and studies on AUD in humans. Additionally, we determine whether behavioral–genetic studies on alcohol in iMOs have identified conserved genetic pathways relevant to human AUD.
