GWAS based on the one-factor GenomicSEM model resulted in 20 significant loci, all of which were also significant in the primary GWAS (Supplementary Table 8 and Supplementary Fig. 40; analysis details in Supplementary Note 5). SNP heritability (assuming a 1% population prevalence) was 6.7% (s.e. = 0.3%), with slightly higher estimates for the clinical (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${h}_{{\rm{SNP}}}^{2}$$\end{document}hSNP2 = 16.4%, s.e. = 1.5%) and comorbid (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${h}_{{\rm{SNP}}}^{2}$$\end{document}hSNP2 = 13.3%, s.e. = 1.7%) subgroups (Supplementary Table 1).
