causal genes, we used S-PrediXcan50 to impute genetically-regulated gene expression in twelve brain tissues and whole blood. The prediction models were trained on reference transcription data from GTEx (brain) and the Depression Genes and Network (DGN) (whole blood) (all available from the PredictDB Data Repository, http://predictdb.org, downloaded on 6/6/2018). Analyses were restricted to the EA data, as the prediction models used by the tools were built using only individuals of European ancestry. We used GTEx v7 to extract gene expression values. Finally, individual genome-wide significant (GWS) SNPs and genes were examined against SNP and gene-based summary statistics for 3,798 GWAS of 2,824 traits, available through http://atlas.ctglab.nl/ (accessed on 10/1/2018).
