Notably, leptin administration is effective in treating obesity. Long-term therapy with subcutaneous injections of recombinant leptin provided sustained beneficial effects on lowering fat mass, hyperinsulinemia, and hyperlipidemia in human obese subjects [33]. These results suggest an important role of leptin in the regulation of the human hypothalamic-pituitary-thyroid axis. It is important to highlight that this strategy is effective for patients with leptin deficiency, but not necessarily applicable as a treatment for common type of obesity.
