These two examples demonstrate that analyses of common single genetic variants, from GWAS and other empirical research, remains relevant and incredibly important in our polygenic world by identifying potentially clinically informative and actionable mechanistic pathways. They also underscore the premise that moderately heritable traits (e.g. PTSD h2 ~40%; (Cornelis et al., 2010)) that impose considerable personal and public health burden (Friedrich, 2017) are worthy of genetic inquiry.
