We repeated the same senstivity analyses as above for SHAS. In Caucasians, there was a significant 2-way time × DAT1 genotype interaction (F7, 613 = 2.20 p= 0.032) and a significant 3-way time × DAT1 gentype × OPRM1 genotype interaction (F7, 613 = 2.50, p = 0.016) on DEQ VAS negative scores. Second, when we added BAC as a covariate and examined effects in all subjects and then in Caucasians only. Findings were similar. Specifically, in all subjects there was a significant 2-way interaction for time × DAT1 genotype (F7, 801 = 2.08, p = 0.043) and a significant 3-way interaction for time × DAT1 gentype × OPRM1 genotype (F7, 801 = 2.46, p = 0.017) on DEQ VAS negative scores. In Caucasians only, there was a significant 2-way interaction for time × DAT1 genotype (F7, 591 = 2.18, p = 0.034) and a significant 3-way interaction for time × DAT1 gentype × OPRM1 genotype (F7, 591 = 2.41, p = 0.02) on DEQ VAS negative scores.
