A whole-brain voxel-based morphometry generalized linear model regression analysis was conducted using SPM12 to test whether alcohol consumption (AUDIT-C) is associated with differences in GMV. Covariates included sex, age, self-reported race/ethnicity (i.e., not-white/white, not-black/black, not Hispanic/Hispanic), scanner identification (2 identical scanners were used), intracranial volume, presence of a diagnosis other than alcohol or substance abuse or dependence, perceived stress, parental education level, early-life stress (assessed via the Childhood Trauma Questionnaire), and perceived SES. Analyses were thresholded at p < .05 familywise error corrected with a cluster extent threshold of 10 contiguous voxels (ke = 10) across the entire search volume.
