also noted an accumulation of Chr19.tRNA10-IleTAT intron (data not shown). Correspondingly, there was a reduction in the amounts of mature tRNAs for Isoleucine and Leucine for mature tRNA IleTAT (pan) and mature tRNA LeuCAA (pan). These results were quantified as the percent mature tRNA or pre-tRNA of total tRNA for each isoacceptor, and demonstrate neural specific changes in pre- and mature tRNA transcript levels.
