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Chunk #21 — Identification of native GABAA receptor subtypes by their pharmacology — Other allosteric ligands

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GABA A receptors: subtypes provide diversity of function and pharmacology.
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In addition to benzodiazepines, other allosteric modulators of GABAA receptors such as general anesthetics of diverse chemical structure, including volatile agents and intravenous anesthetics, such as barbiturates, long-chain alcohols, neuroactive steroids, etomidate, propofol, as well as ethanol (Olsen & Sieghart, 2008) can be used for the identification of specific GABAA receptor subtypes.