(from mild deficits in ARBD to moderate or severe deficits in WKS) in the mamillary bodies, hippocampus, thalamus, cerebellum and pons (Figure 4).5 As brain regions outside those traditionally associated with thiamine depletion (for example, the frontal cortices, hippocampus and pons) are affected in both uncomplicated alcoholism and KS, alcohol ism alone or in combination with nutritional deficiencies may have roles in the mechanisms under lying these brain abnormalities. Indeed, multiple subclinical episodes of thiamine deficiency or other nutritional deficiencies may contribute to the graded nature of brain regional volume deficits and to the heterogeneity in presenting signs and neuro radiological profiles in patients with alcoholism.79
