Despite being in a nascent stage of methodological development, hiPSC-derived neurons show promise for modeling molecular and cellular deficits of SZ. Because of the complex etiology and great genetic variability of the disorder, a patient-specific approach may be illuminating from a mechanistic perspective as well as for drug screening. Already, hiPSC-derived neurons have recapitulated deficits in synaptic maturation and connectivity. Furthermore, advances in generating organoids show promise for modeling network activity in three dimensions, thus better recapitulating brain development and circuitry.
