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Chunk #32 — Discussion — Dietary fat and ethanol synergize in raising TG levels

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Positive relationship between dietary fat, ethanol intake, triglycerides, and hypothalamic peptides: counteraction by lipid-lowering drugs.
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markedly elevated levels of circulating TG compared to water-drinking rats after this HFD meal or ethanol-drinking rats after a LFD meal. The failure of ethanol, when combined with a LFD, high-carbohydrate meal, to raise TG levels compared to water alone with this meal may be due to the enhanced metabolism and clearance of ethanol from the blood associated with carbohydrate intake (Rogers et al., 1987; Yonekura et al., 1993). In addition to underscoring the similarity of ethanol and dietary fat in raising circulating TG, this experiment reveals an interaction effect between ethanol and dietary fat on circulating TG.