Although significant progress has been made in elucidating the molecular determinants of eCB signing in the brain (Kano et al., 2009), global functional properties have been scantly discussed in the literature. Here we suggest a structural framework, derived from both anatomical and physiological data, for describing what we consider to be a fundamental functional motif of the eCB signaling system that modulates forebrain cortico-striato-pallidal circuits (Fig. 2).
