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Chunk #16 — Results

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Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.
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For AD+DD in the case-control sample, seven nominally significant individual SNPs emerged: T6, T7, T8, A5, A6, D1 and D2 (p = 0.049 to 0.0025), though none was significant after Bonferroni correction, as shown in Table 2. The global haplotype analyses revealed three risk regions: almost the entirety of TTC12, the two merging 3′ regions of DRD2 and ANKK1, and around exon 12 of NCAM1.