in the trio was genotyped on microsatellite markers. The dTDT is applied on these trio pedigrees using their inferred dosage probabilities. In addition, PLINK 77 is used to conduct a standard case-control study on the CIDRSNP data. With the idea that making use of all the available sample data would increase the power for association detection, we further combine the results from both dTDT and case-control study through the MH test [78].