probably define the nodal gene of these subsets (Supplementary Table 2, Supplementary Figure 6) and we observe two highly cell specific examples in the form of KLF4 (Supplementary Figures 7,8) and LYZ (discussed below). We found that only 7% of trans-eSNPs are shared between cell types, implying trans-eQTLs show a greater degree of cell specificity than cis-eQTLs. Given that B-cells constitute ~5% of PBMCs and monocytes 10-15%13, cell specific traits will often be undetectable in eQTL analysis of a heterogeneous population of PBMCs due to saturation of cell specific signals by expression signatures from other cell types.
