diagnosis were increased by 5%. Findings such as this point to the potential value of using endophenotypes to identify those at genetic high risk well before they become symptomatic. A longitudinal research strategy built from a sample enriched in this way makes it possible to study individuals in the prodromal period preceding disorder development. In turn, such an enriched sample provides an opportunity to identify factors that differentiate those at high risk who succumb from those at high risk who do not.
