Based on the single marker results above, we limited FH analyses to the most significantly associated markers, rs7597593 and rs1344706 (Table S3). Using the categorical definitions described in Methods, there are 196 FH+ and 478 conservatively defined FH− cases (no illness reported in first or second degree family members) in the ICCSS sample. A genotype at rs1344706 was missing for 23 individuals with family history (15 FH− and 8 FH+), leaving a total analyzed sample N=651 (1302 alleles), 463 FH− and 188 FH+. There is no evidence of any difference in association of rs1344706 and rs7597593 between FH+ and FH− cases (Table S3).
