In summary, the increased ACC-FEF phase synchrony and also increased influence of the ACC over FEF during the delay period suggests that the ACC-FEF interaction serves a functional role. The increased ACC unit-FEF LFP coupling in the delay period of the contraversive saccades could indicate that the ACC biases FEF to generate a contraversive saccade (Fig. 8). Our results also suggest that FEF sends target location (or saccade target) signals to the ACC through increased FEF unit-ACC LFP coupling in the delay period of contraversive saccades (Fig. 8). We believe that selective theta and beta frequency coherence of the FEF and ACC during working memory delays reveals how top-down information is actively coordinated to ensure the optimal harvesting of rewards during top-down controlled behaviour. We speculate that theta cycles may provide the critical reference for neuronal spikes in distributed brain systems to code for goal- and choice-relevant information143155.
