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Chunk #9 — Limitations and cautions for interpretation of polygenic risk score

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Polygenic risk scores in psychiatry: Will they be useful for clinicians?
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in the primary GWAS, but application of those data to independent samples of different ethnicity to the discovery sample is especially prone to errors and fraught with potential misinterpretation 16, 17. For this reason (among many others), it is imperative that, rather than applying recent Eurocentric approaches, future GWAS include analyses of subjects from diverse ethnic backgrounds, improving generalizability and utility of these results for all populations 21, and efforts are under way to resolve this crucial issue.