For both ADHD-C group and control group the resting BOLD time series for the NAcc was correlated with all other voxels in the brain, generating voxelwise functional connectivity maps. We performed two-sample two-tailed t-tests on all potential connections (Fisher transformed r-values) to compare ADHD-C children and controls (assuming unequal variance; p ≤ 0.05). The voxelwise approach provides three different maps for the seed region: an ADHD-C map, a control map, and a map representing the direct comparison between the groups. To account for multiple comparisons, thresholding based on Monte Carlo simulation was implemented (Forman et al., 1995). To obtain multiple comparisons corrected, p < 0.05 voxel clusters, a threshold of 53 contiguous voxels with a Z-value > 2.25 was used.
