In the GWAS discovery set, 2,261 ALS cases and 8,328 patients remained after quality control measures with genotypes for 268,952 SNPs. Details of included study populations are shown in Table S2. Association analysis resulted in one SNP (rs12608932 in gene UNC13A) with genome-wide significance (p = 1.7×10–8) after Bonferroni correction for 268,952 SNPs. A Manhattan plot of genome-wide results is shown in Figure S1. A quantile-quantile plot of disease association p values is provided in Figure S2 (genomic control λ = 1.03). There were 14,167 autosomal SNPs with a nominal p value <0.05. These SNPs were used to prioritize eQTLs found in the eQTL discovery set (Figure 1).
