Chunk #8 — Results and discussion

Source

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.

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We note that greater numbers of AA and Hispanic/Latino individuals will be included in future releases of sequencing datasets from TOPMed, which we anticipate will further improve imputation quality; inclusion of JHS itself in imputation for other AA cohorts would also improve imputation quality.