Chunk #22 — HOW DO NEURAL SIGNATURES ASSOCIATED WITH AUD HELP ELUCIDATE THE ROLE OF BRAIN FUNCTION IN THE RISK AND CONSEQUENCES OF ALCOHOL USE AND AUD ACROSS THE LIFESPAN?
inception through the current Lifespan project and are considered to be the “core” phenotypes that can be used for analyses on the whole sample as well as in longitudinal analyses (>7000 participants have data at more than one timepoint). Examining resting state EEG, COGA have reported increased EEG beta power (12–28 Hz) in individuals with AUD and in their offspring. 23 , 24 Beta rhythm is an index of neural excitability, 99 and the increased beta power in individuals with AUD and at‐risk family members is indicative of an imbalance in excitation/inhibition in neural networks. While increased beta was found for both genders, it was more pronounced in males than females, and related to family density of AUD, especially increased in those with two or more first‐degree relatives with AUD. 77 COGA has also found increased resting state EEG interhemispheric coherence (Figure 1B) in several frequency bands in individuals with AUD and their offspring; it was not found to be related to length of abstinence from alcohol. 19 , 28
