significant ADH1B SNP in the EA subsample (p=7.77 × 10−14) and rs2066702 was the most significant SNP in the AA subsample (5.73 × 10−17) (Gelernter et al., 2014), we examined ADH1B variants of greatest effect in each population. Third, we examined potential distinctions by sex in the contributions of ADH1B variants and childhood adversity to alcohol phenotypes, a key issue to address given the lower rates of alcohol consumption and AUD (Chan et al., 2007, Keyes et al., 2008), higher prevalence of traumatic events associated with alcohol-related problems (e.g., sexual abuse) (Fergusson et al., 1996b, Pereda et al., 2009), and evidence of greater resilience to the effects of trauma on psychiatric and substance use problems (DuMont et al, 2007; Schilling et al., 2007) in women than men.
