The BroadABC antisocial genetic risk scores could predict case-control status of antisocial personality disorder in the Finnish Crime Study (sex-combined, p=.031; male-specific, p=.05, in the most optimal model, see Figure 2A and 2B). Nevertheless, the analyses revealed low Nagelkerke’s R2 estimates (R2=.0019 in the most optimal model) not exceeding the Bonferroni corrected threshold for significance. Using summary statistics in PRsice software, we found that the genetic effect from the females-only ASB analysis significantly overlapped with genetic effects in the expected direction on conduct problems in MSUTR (p= .004, R2=.021 for the most optimal model, see Figure 2E), but not with the sex-combined and males-only analyses (Figure 2C and 2D). No significant genetic overlap was found with conduct disorder in YalePenn, although a nominal significant effect (p=.04, R2=.0022) in the expected direction was found in the males-only analysis (Figure 2E, 2F and 2G).
