heavy drinkers used to predict the escalation of baseline heavier drinking and binges (e.g., King et al., 2014). While it is possible that different methodologies to evaluate alcohol sensitivity might identify identical genes, researchers must consider that different combinations of genes might contribute to sensitivity measured through different approaches. This phenomenon might diminish the ability of meta-analyses and GWAS to consistently identify genes with small effects on how a person responds to alcohol. The optimal approach might be to first evaluate potential associated genes separately for oral alcohol administrations, IV dosing, and retrospective questionnaire-based measures before combining them into a single analysis.
