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Chunk #43 — Online methods — Replication of novel GERA SNPs using ICBP and UKB

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Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
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To test the 39 novel GERA genome-wide significant SNPs for replication, we evaluated the associations utilizing a fixed effects meta-analysis of ICBP and UKB. We also tested the 36 novel SNPs found in the meta-analysis of GERA and ICBP for replication in UKB. We report associations that replicate at a strict Bonferroni threshold (P<0.00067, to account for a total of 75 novel SNPs tested), as well as suggestive (P<0.01) and nominally suggestive (P<0.05) findings with effects in the same direction as the original.