The age-adjusted mean AUDIT-C score was more strongly associated with genetic polymorphisms of known risk for AUD than were trajectories of AUDIT-C or AUD diagnostic codes. Both our recent publication (8) from the Veterans Aging Cohort Study sample and the findings from the current study in the MVP sample show that it is feasible to use EHR data to derive a phenotype for harmful alcohol use that has considerable potential utility for gene discovery.
