paperKB
coga / coga-kb
Help
Sign in

Chunk #0 — Introduction

Source
Genome-Wide DNA Methylation Profiling Reveals Epigenetic Changes in the Rat Nucleus Accumbens Associated With Cross-Generational Effects of Adolescent THC Exposure.
Embedded
yes

Text

Marijuana (Cannabis sativa) is the most commonly used illicit drug by teenagers and young adults in Western countries, with significant controversies regarding its immediate and long-term effects (SAMHSA, 2011; Ammerman, 2014). Alarmingly, marijuana use now exceeds that of tobacco in youths (Johnston et al, 2012). Recent movements regarding the legalization of Cannabis for medical or recreational purposes have sparked intense debates, yet controversies surrounding marijuana regarding medical, political, and societal issues have largely lacked scientific input (Hopfer, 2014). Despite the public perception that Cannabis is a relatively safe drug, there is now evidence that its abuse can lead to dependence, especially in individuals with vulnerable genetic backgrounds, as well as with neuropsychiatric abnormalities such as anxiety, depression or psychosis (Hurd et al, 2014).