We are not aware of any other methods designed to estimate genome-wide components of heritability from summary statistics. However, there are existing methods that identify enriched functional categories and cell types from summary statistics. We compared our method to four other methods, described below; each of these methods has provided valuable biological insights. For each of these methods, we assessed the rejection rate over 100 simulations for true cell-type-specific enrichment, null baseline enrichment (i.e., baseline enrichment with no cell-type-specific signal), and null simulations with no enrichment in any category. We performed this analysis for both a cell type (fetal brain in H3K4me3) and cell-type group (CNS), and for two proportions of causal SNPs, 0.05 and 0.005. All simulations had a sample size of 14000 and hg2 of 0.7. Results are displayed in Figure 7; below, we discuss the results for each method individually.
