myocardial hypertrophy, and cardiovascular disease progression. We recently observed that inflammatory changes in fat tissue are linked to systemic arterial dysfunction and abnormal clinical phenotypes, which suggests the possibility of a pathogenic adipose-cardiovascular axis.4 Although BMI is useful in predicting overall risk, other factors, including adiposity distribution, degree of visceral or ectopic fat burden, percent body fat, genetic factors, sex, and possibly qualitative features of adipose tissue, may be germane to clinical disease expression.5,6
