The aim of the current study was to identify SNPs associated with age at smoking initiation, smoking cessation, current and lifetime average CPD among COPD subjects, using GWAS in four independent cohorts: National Emphysema Treatment Trial (NETT), Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE), GenKOLS cohort from Bergen, Norway, and COPDGene. We hypothesized that a subset of smoking behavior genetic determinants in other population samples would influence smoking behavior in COPD subjects.
