Chunk #22 — Discussion

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Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol.

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likely occurs through allosteric changes in the channel that alter the rates of association and dissociation of PIP2. On the other hand, stimulation of GPCRs that couple to Gq G proteins can reversibly lower the levels of membrane PIP2, leading to a decrease in GIRK channel activity58.