a P-value of 6.33E-08 (Lai, Wetherill, Kapoor, et al., 2019). In the current admixture mapping analysis, this region was marginally associated with SRE-5 (P-value=0.08), with African ancestry increasing SRE-5 scores, which is in agreement with the prior GWAS result. This much higher P-value could be due to the large size of the inferred African ancestry block: it is about twice the size of the identified region in previous GWAS, and included only one association signal; therefore, the regional effect size might have been too small to be detected by admixture mapping.
