In summary, we have shown that the genetic signature for opioid misuse that we were able to capture via self-report in an unselected population is similar to genetic risk for OUD. Our work sets the stage for future analyses incorporating a multivariate framework (e.g., genomic Structural Equation Modeling), and larger sample sizes. Our approach provides new, cost-efficient tools for genetic research related to OUD and provides insights into an intermediate behavior that may set the stage for later transition to OUD.
