TagSNP selection strategy.HapMap genotypes for European individuals were obtained from the HapMap database. For each candidate gene, SNPs within the gene region±10 Kb were included. A MAF ≥5% and an r2 = 0.8 were used for tagSNPs selection using Haploview. Variants with a MAF ≥2% were analyzed in the gene re-sequencing set, with r2 = 1.0. Using a two-stage approach, we selected 682 tagSNPs that represent 1550 non-redundant variants from gene re-sequencing and HapMap data sets. tagSNPs (120) representing the 179 shared variants found in both data sets were determined in the gene re-sequencing set. CNS = conserved non-coding sequences.
