Chunk #43 — Online Methods — Variant detection

Source: Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples.
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LODT(m,f)=log10(L[Mfm]P(m,f)L[M0](1-P(m,f)))≥log10δT and set δT to 2 to ensure that we are at least twice as confident that the site is variant as compared to noise. We can then also rewrite LODT as: LODT(m,f)=log10(L[Mfm]L[M0])≥log10δ-log10(P(m,f)(1-P(m,f)))=θT