Chi-square test was used to evaluate dichotomous variables of HADS-A and HADS-D. Binary multivariate logistic regression was used to estimate odds ratios (OR) for the association between genotype and each of the two HADS subscales, i.e. depression and anxiety disorder (dependent variable). Potential confounding was evaluated by adjusting for sex, age (5-year categories) and ischemic heart disease. The precision for the OR was estimated with 95% confidence interval (CI).
