Under this model, approval is positively associated with trait similarity for supporting GWAS and OMIM associations, with 95% credible intervals excluding zero (Fig 2A). When associated traits are sufficiently similar (for GWAS, roughly the similarity between Stomach Neoplasms and Colorectal Neoplasms), gene target-indication pairs with GWAS or OMIM associations are more likely to be approved. Evaluation of the data also revealed when there is a genetic association for a dissimilar disease, they are less likely to be approved than gene target-indication pairs with no known genetic association. This negative association is a novel finding.
