frequency core haplotype for which homozygosity has been maintained rather than broken down by recombination relative to other core haplotypes. The SNPs we identified in COMT for which the derived alleles make up a high-frequency haplotype with relatively greater homozygosity than other EA haplotypes are good candidates to contain functional SNPs, although they did not show significance in single SNP association analysis in this study. As in the haplotype association analysis in this study, patterns seen were population-specific.
