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Chunk #36 — Discussion — rs-fcMRI may reflect an interaction between the maturing neural substrate and the use of efficient pathways for general task completion — Changes in the neural substrate over development may lead to more efficient neural pathways for general task completion

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Functional brain networks develop from a "local to distributed" organization.
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We note that recent results in the aging literature suggest that many of the trajectories observed in the current manuscript continue inversely with advancing age [24],[78]. That is, with aging, the functional organization, revealed via rs-fcMRI, becomes less distributed and more local. Thus the dynamic interactions we describe here likely continue as part of normal senescence [78].