Here, we apply a comprehensive approach to the investigation of genomic influences on AP in a population-based sample of emerging adults in the United Kingdom. This is a critical time frame for the establishment of drinking behaviors [27] and the development of alcohol use disorders [28]. We use GWAS results to identify genes and gene ontologies likely to play a role in the etiology of AP. We further test whether the implicated SNPs map to hypothesized regions of regulatory significance across a variety of tissues. Finally, we examine the aggregate effects of common variants.
