Chunk #35 — Reasons to be Concerned about the Published cGxE Literature — The Ingredients of cGxE: The Choice of Genetic and Environmental Variables — The Choice of “G”
Young, Lawford, Nutting, & Noble, 2004). Subsequently, it was discovered that the polymorphism was actually located in the neighboring gene ANKK1 (Neville, Johnstone, & Walton, 2004). More systematic studies of genetic variation across the region containing ANKK1 and DRD2 have found evidence that multiple genes may be involved (Gelernter et al., 2006; B.Z. Yang et al., 2007; B. Z. Yang et al., 2008). Differences in the way that individual genes, gene networks, and whole genomes are systematically studied has led to increasing distance between the gene finding world and studies of cGxE, which still focus largely on the “usual suspect” candidate polymorphisms. Clearly, better integration of these research areas is necessary.
