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Chunk #44 — DISCUSSION

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Early life stress, MAOA, and gene-environment interactions predict behavioral disinhibition in children.
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We regard this as an exploratory study since it was not clear a priori which stressors would have the greatest effect in this population sample. Any correction for multiple testing would render most of the results non-significant. This is a general population sample and there was not much variability in hyperactivity scores and even less variability in conduct scores. Moreover, the SDQ scales are not a measure of pathological behavior. Nevertheless, the strength of this study is that because we had a very large sample we were able to detect a modest effect of MAOA-LPR × early life stress on behavioral disinhibition in a general population sample of children in which few had been exposed to severe adversity.