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Chunk #8 — Results — Autism Subphenotypes and Covariates

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Genome-wide linkage analyses of quantitative and categorical autism subphenotypes.
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Table 2 lists the associations between the subphenotypes used in this study. The subphenotypes SOC and BEH were significantly correlated (r = .28, p < .0001). The associations between the two quantitative traits and the binary traits were different. The subphenotype SOC was positively associated with DelayedWord and DelayedPhrase but negatively associated with Verbal and IQ ≥ 70 (all p < .0001). In other words, the mean scores for SOC were higher in the affected groups defined by DelayedWord and DelayedPhrase than the mean scores in the unaffected group but were lower in the affected groups defined by Verbal and IQ ≥ 70 than the mean scores in the unaffected group. On the other hand, BEH was not associated with DelayedWord (p = .7), DelayedPhrase (p = .6), and IQ ≥ 70 (p = .9) but was positively associated with Verbal (the verbal group had higher BEH scores than the scores in the nonverbal group with p < .0001). As expected, DelayedWord and DelayedPhrase were positively associated with each other (if an individual had delayed onset of first words, he/she