We acquired summary statistics from large-scale GWAS of major mental disorders ADHD, BIP, MD, schizophrenia, as well as educational attainment (EDU), general intelligence (hereafter “intelligence”), neuroticism, subjective well-being (SWB), and height (table 1, supplementary table 1).15,21–31 Phenotypes were selected based on available sample size and the quality of phenotyping procedures (supplementary methods, supplementary tables 2-3). The final sample included 268,241 individuals with mental disorder and a combined sample size of 3,571,567, although there was participant overlap across samples.32 Due to the confounding effect of ancestral differences in LD structure and the lack of sufficiently powered multi-ancestry samples, samples were restricted to European ancestry. The Regional Committee for Medical Research Ethics – Southeast Norway evaluated the current protocol and found that no additional institutional review board approval was necessary as no individual data were used.
